Consuming oranges grapefruit and some other known types of oranges may cause adverse reactions when combined with certain drugs. The most recent research indicated, this risk turned out to be much larger than previously thought.
Research published in the Journal of the Canadian Medical Association stated, grapefruit and other citrus types can cause death, acute kidney failure, Lung failure, intestinal bleeding, and a range of other serious health problems because of interactions with certain drugs.
As many as 85 reported drugs may interact with grapefruit, and 43 of which can cause serious side effects.
This reaction occurs because the active ingredients in fruit that is a compound that inhibits an enzyme called furanocoumarin work inside the body. In addition, these compounds can also increase the dosage of the drug become several times more, so that it can lead to over dose. In addition to other types of grapefruit, citrus such as lemon and oranges also contain furanocoumarin compounds slogan.
Medications that can interact with other compound in grapefruit drug among anti-hypertension drug, an anti-cancer, anti-drugs and cholesterol.
Dr David Bailey, a scientist from Canada says, "though side effects are quite dangerous, but grapefruit can also be helpful for some types of certain treatments. But recently the discovery reveals the negative effects of grapefruit against drugs increased from 17 to 43 drug during 2008 to 2012. This makes his ascent more than 6 medications per year. "
Bailey added, "the current knowledge about drug interactions and food is still lacking, both from health practitioners and patients."
For a drug with effects that low, furanocoumarin can enhance the effect. But for a drug with effects that are already high, furanocoumarin instead will lead to over dose of up to 330%.
Because higher risks in using grapefruit or lime in other drug dose increase, so their use is not possible in general practice. "The understanding is very important, so that both doctors and patients need to be careful in utilizing the effect of grapefruit," said Bailey.
Research published in the Journal of the Canadian Medical Association stated, grapefruit and other citrus types can cause death, acute kidney failure, Lung failure, intestinal bleeding, and a range of other serious health problems because of interactions with certain drugs.
As many as 85 reported drugs may interact with grapefruit, and 43 of which can cause serious side effects.
This reaction occurs because the active ingredients in fruit that is a compound that inhibits an enzyme called furanocoumarin work inside the body. In addition, these compounds can also increase the dosage of the drug become several times more, so that it can lead to over dose. In addition to other types of grapefruit, citrus such as lemon and oranges also contain furanocoumarin compounds slogan.
Medications that can interact with other compound in grapefruit drug among anti-hypertension drug, an anti-cancer, anti-drugs and cholesterol.
Dr David Bailey, a scientist from Canada says, "though side effects are quite dangerous, but grapefruit can also be helpful for some types of certain treatments. But recently the discovery reveals the negative effects of grapefruit against drugs increased from 17 to 43 drug during 2008 to 2012. This makes his ascent more than 6 medications per year. "
Bailey added, "the current knowledge about drug interactions and food is still lacking, both from health practitioners and patients."
For a drug with effects that low, furanocoumarin can enhance the effect. But for a drug with effects that are already high, furanocoumarin instead will lead to over dose of up to 330%.
Because higher risks in using grapefruit or lime in other drug dose increase, so their use is not possible in general practice. "The understanding is very important, so that both doctors and patients need to be careful in utilizing the effect of grapefruit," said Bailey.
